The xanthine oxidase-aldehyde system

P-91: Vitamin E and Selenium Supplementation Affects Aldehyde Oxidase, Xanthine Dehydrogenase/Oxidase Activities In Diabetic Rat Ovaries

Background Any factor like diabetes that changes the oxidant/antioxidant balance in favor of oxidants could possibly disrupt the physiologic function of ovaries. So, we have investigated the effect of vitamin E and Se supplements on antioxidant defense in ovaries of diabetic rats with focus on Xanthine dehydrogenase/oxidase (XDH/XO) and Aldehyde oxidase (AO) activities. MaterialsAndMethods This...

Role of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of Purine-Related Drugs

Purines are natural compounds that are found in all of the body's cells. They are the most widely distributed kind of N-heterocyclic substances in nature. Purines provide part of the chemical structure of some important co-enzymes and the genes of plants and animals. These compounds also participate in membrane signal transduction, translation and protein synthesis and in the form of purine nuc...

In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase.

In spite of over 40 years of clinical use of 6-mercaptopurine, many aspects of complex pharmacology and metabolism of this drug remain unclear. It is thought that 6-mercaptopurine is oxidized to 6-thiouric acid through 6-thioxanthine or 8-oxo-6-mercaptopurine by one of two molybdenum hydroxylases, xanthine oxidase (XO), however, the role of other molybdenum hydroxylase, aldehyde oxidase (AO), i...

Crystal structure and mechanism of action of the xanthine oxidase-related aldehyde oxidoreductase from Desulfovibrio gigas.

The crystal structure of the aldehyde oxidoreductase (Mop) from the sulphate-reducing bacterium Destdjovibrio gigas has been analysed and refined to 1.8A (0.18 nm) resolution in its native ‘desulpho’ form, as well as in ‘resulphurated’, oxidized, reduced and alcohol-bound forms [1,2], allowing a detailed look at several structural aspects relevant to catalysis. In analogy with eukaryotic xanthi...

The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of mGlu5